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PROFESSIONAL EXPERIENCE SUMMARY

Seattle Genetics, Inc. (2006 - 2014)

Associate Director, Experimental Pathology (2009-2014)
Veterinary Pathologist, Pharmacology and Toxicology  (2006 – 2009)
Corixa, Corp. (2004 – 2006)
Veterinary Pathologist II, Nonclinical Dept.
Shin Nippon Biomedical Laboratories, Ltd. (2002 – 2004)
Research Pathologist, Pathology Dept. ​
United States Army (1990 – 2002)
U.S. Army Medical Research Institute of Infectious Diseases (2000 – 2002)

Chief, Applied Research Support and Immunohistochemistry

U.S. Army Medical Research Institute of Chemical Defense (1998 – 2000)

Staff Pathologist, Comparative Pathology Department 

Armed Forces Institute of Pathology (1995 – 1998)

Veterinary pathology resident, Veterinary Pathology Department                                                                      ​                        


Dr. Steven Duniho CV

EDUCATION
Armed Forces Institute of Pathology, Washington, DC (1995 – 1998)
Diplomate, American College of Veterinary Pathologists 
University of Missouri, Columbia, MO (1986 – 1990)
Doctorate of Veterinary Medicine
​Southwest Missouri State University, Springfield, MO (1983 – 1986)
Biology Major 

PROFESSIONAL MEMBERSHIPS
Washington State Veterinary License (2001 – Present)
American College of Veterinary Pathology (1999 – Present)
​Society of Toxicologic Pathology (1999 – Present)

PUBLICATIONS

​​Targeting pancreatic and ovarian carcinomas using the auristatin-based anti-CD70 antibody-drug conjugateSGN-75.

Br J Cancer. 2010 Aug 24;103(5):676-8.

​• ​​Blocking of CD27-CD70 pathway by anti-CD70 antibody 2009 ameliorates joint disease in murine collagen-induced arthritis.

J Immunol. 2009 Sep 15;183(6):3770-7.

​• ​​Preclinical characterization of SGN-70, a humanized antibody directed against CD70. 
Clin Cancer Res. 2008 Dec 1;14(23):7763-72.
​• ​​Toxicity in rhesus monkeys following administration of the 8-aminoquinoline 8-[(4-amino-l- methylbutyl)amino]-5-(l-hexyloxy)-6-methoxy-4-
methylquinoline (WR242511).
J Med Toxicol. 2008 Sep;4(3):157-66.
​• ​​CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers.
Br J Cancer. 2008 Jul 8;99(1):100-9.
​​Phase I Trial of sequential administration of recombinant DNA and adenovirus expressing L523S protein in early stage non-small-cell lung cancer.  
Mol Ther. 2006 Jun;13(6):1185-91.
​​Development of a Guinea pig model for low-dose, long-term to organophosphorus nerve agents.
Toxicol Mech Methods. 2004;14(3):183-94.
​​Pulmonary gene expression profiling of inhaled ricin.
Toxicon. 2003 Jun;41(7):813-22.
​​Control of nerve agent-induced seizures is critical for neuroprotection and survival.
Toxicol Appl Pharmacol. 2003 Apr 15; 188(2): 69-80.
​​Impact of inhalation exposure modality and particle size on the respiratory deposition of ricin in BALB/c mice.
Inhal Toxicol. 2003 May;15(6):619-38.
​​Control of nerve agent-induced seizures is critical for neuroprotection and survival.   
Toxicol Appl Pharmacol. 2003 Apr 15;188(2):69-80.
​​Pulmonary gene expression profiling of inhaled ricin.
Toxicon 2003 Jun; 41(7): 813-22.
​​Acute changes in lung histopathology and bronchoalveolar lavage parameters in mice exposed to the choking agent gas phosgene.
Toxicol Pathol. 2002 May-Jun;30(3):339-49.
​​Acute Changes in Lung Histopathology and Bronchoalveolar Lavage Parameters in Mice Exposed to the Choking Agent Gas Phosgene.
Tox Path. 2002 May; 30(3): 339-349.
​​Dyspnea in Yorkshire-cross weanling swine. Diagnosis: ventricular septal defect.
Lab Anim (NY). 2001 Nov; 30(10): 23-5.
​​A subependymal giant cell astrocytoma in a cat.  
Vet Pathol. 2000 May;37(3):275-8.
​​Abdominal spindle cell sarcoma of probable myofibroblastic origin in a horse.
Vet Diagn Invest. 1999 May;11(3):278-82.